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Indian Institute of Chemical Biology

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INTRODUCTION:

 
IICB was established in 1935 as the first non official centre in India for biomedical research and was included within the aegis of CSIR in 1956.IICB is one of the major laboratories in India which initiated, right from its inception, multidisciplinary concerted efforts for conducting basic research on infectious diseases, specifically leishmaniasis and cholera, along with the development of technologies for the diagnosis, immunoprophylaxis, and chemotherapy of the diseases.
 
Major Departments and areas in field of Research are:
  • Cell Biology
  • Physiology
  • Chemistry
  • Human Genetics
  • Molecular Genetics
  • Infectious Diseases
  • Biotechnology
  • Structural Biology
  • Bio-Informatics
 
CONTRIBUTIONS TO THE FIELD OF SCIENCE:
 
The institute has developed an oral vaccine for cholera, herbal products for controlling gastric ulcer, empirical treatment for vitiligo, diagnostic kits for malignancy and hormonal disorders, fungal enzymes of industrial importance, radiopharmaceuticals for evaluation of the functional status of renal and hepatobiliary systems and a device for early detection of Parkinson's disease. Although the strength of IICB has always been basic biomedical research, during the last decade emphasis is being given on goal oriented research directed towards commercial exploitability. Efforts are now on to convert the knowledge gained over the years through high quality basic research into wealth.
 
Bioactive substances from natural sources and chemically synthesized new molecules are being explored as potential drugs. Other areas being actively pursued are gastric hyperacidity and ulcer, muscular dystrophy and related disorders, macromolecular structure function analysis, development of targeted drug delivery systems, sperm biology and protein chemistry and enzymology.
 
The following R & D activities have been successfully carried out in IICB:
  • Thyroid hormone stimulates  g-glutamyl transpeptidase in the developing rat cerebra and in astroglial cultures.
  • Docosahexaenoic acid facilitates cell maturation and beta adrenergic transmission in astrocytes.
  • Analysis of Differentially Expressed Genes in Hyperthyroid-Induced Hypertrophied Heart by cDNA Microarray. J. Endocrinol.
  • Role of sulfhydryl groups in band 3 in the inhibition of phosphate transport across erythrocyte membrane in visceral leishmaniasis.
  • An agaroid-carrageenan hybrid type backbone structure for the antithrombotic sulfated polysaccharide from Grateloupia indica Boergensen (Halymeniales, Rhodophyta),  Botanica Marina.
  • Synthesis of linear pyridine-fused ring systems by endo-selective 2-pyridyl radical cyclizations.
  • "Ping-Pong" interactions between mitochondrial tRNA import receptors within a multiprotein complex.
  • Characterisation of the DNA-binding domain and identification of the active site residue in the Gyr a half of Leishmania donovani topoisomerase II.
  • Lack of abundance of cytoplasmic CsA-binding protein renders free-living Leishmania donovani resistant to cyclosporinA
The following training programmes ae also sponsored by IICB for the benefit of students and college graduates:
 
  • Ph.D. Programme
  • Summer Training
  • Project Work
  • Dissertation Work
  • Nomination in Training and Workshop 
IICB today is engaged in research on diseases of national importance and biological problems of global interest, employing sophisticated state-of-the-art technology in keeping with the rapid and unprecedented momentum that life science research has gained globally over the last 50 years. The scientific staff has expertise in a variety of areas including chemistry, biochemistry, cell biology, molecular biology, neurobiology and immunology which promotes productive interdisciplinary interaction.

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